ISIB is a public research institution within the Czech Academy of Sciences, active in measurement and Description technology method development in the fields of magnetic resonance, coherence optics and electron microscopy. The MR group Group (17 members, total 14 FTE incl., PhD students 6 FTE), involved in INSPiRE-MED, focuses on measurement and data analysis techniques for biomedical and technological applications of NMR. Its main research topics are MR spectroscopy methods for metabolite concentration quantitation, and quantitative MR imaging of perfusion (incl. pharmaco¬kinetics modeling) and diffusion. The MR Group runs a MR Unit that is a part of a bioimaging service node included in the government-recognized large infrastructure Czech-BioImaging and listed as a part of a Euro-BioImaging (ESFRI, in preparatory phase) node candidate; as such, the group specializes in ultra-high field MR examinations of small animal models and provides imaging service to external researchers.
ISIB participated in the EC grant FP7-PEOPLE-2012-ITN #316679 – “Transforming Magnetic Resonance Spectroscopy into a Clinical Tool” (TRANSACT)” and contributed to multiple key areas like extension of spin system simulation and of the jMRUI package (www.jmrui.eu), software development coordination and integration for standardization, automation, Training quality assurance. ISIB also participated in EC grant FP6-MC-RTN-035801 – “Advanced Signal-processing for Ultra-Fast Magnetic Resonance Spectroscopic Imaging, and Training” (FAST): development of a virtual scanner. Ministry of Education, Youth and Sports of the Czech Republic (MEYS) grant CZ.1.05/2.1.00/01.0017 – “Application Laboratories of Advanced Microtechnologies and Nanotechnologies” (ALISI): establishment and startup of an experimental centre. Czech Science Foundation (CSF) grant GA15-12607S – “Design and optimization of ultra-short echo- time sequence for reliable detection of myelin content in the human brain by magnetic resonance imaging”: pulse sequence and image reconstruction development. Before 2005, Z.S. and J.S. participated in projects on: spectroscopic pulse sequence development, shim and gradient coil design, software for quantum-mechanical simulation of selective excitation in NMR (Romag, Romagamma), software Marevisi for NMR data processing and visualization (IBD NRC Canada, written by J.S. and Z.S.).
ISIB is currently actively involved in several research projects. MEYS grant LM2015062 – “National Infrastructure for Biological and Medical Imaging”: providing MR imaging services for biomedical research of client institutions or companies, and grant CZ.02.1.01/0.0/0.0/16_013/0001775 supporting method development and extension of the MR Unit. MEYS grant LO1212 – “ALISI – Centre of advanced diagnostic methods and technologies”: development of MR techniques for practical applications. CSF grant GA16-13830S – “Magnetic resonance perfusion imaging using compressed sensing”: development of pulse sequences and data analysis algorithms and software.
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